Early Translational Research Awards

Limited Submission Funding Opportunity for Texas A&M Faculty and PIs

CPRIT

Early Translational Research Awards

http://www.cprit.state.tx.us/images/uploads/rfa_r-17_1-etra.pdf

 

Limited Submission Program (LSP): This funding opportunity and the Limited Submission Program (LSP) is open to all Texas A&M University faculty and principal investigators who meet the eligibility requirements. Texas A&M and The Texas A&M University System agencies jointly administer this process to select the proposal(s) that will be submitted to the sponsor in response to this solicitation.

 

Institutional Eligibility:  The applicant must be a Texas-based entity. Any not-for-profit institution that conducts

research is eligible to apply for funding under this award mechanism.  Because a large number of submissions is anticipated, and to ensure timely and high-quality review of the most innovative and cutting-edge research with the greatest potential for advancement of cancer research, CPRIT is imposing a limit on the number of ETRA applications that may be submitted by an institution during this review cycle.  Texas A&M University, 10; Texas A&M University Health Science Center, 10.

 

PI Eligibility: 

  • The Principal Investigator (PI) must have a doctoral degree, including MD, PhD, DDS, DMD, DrPH, DO, DVM, or equivalent and must reside in Texas during the time the research that is the subject of the grant is conducted. 
  • A PI may submit only 1 application under this RFA during this funding cycle. 
  • Because this award mechanism is intended to support research directed by a single investigator, only 1 Co-Principal Investigator (Co-PI) may be included. 
  • Collaborations are permitted and encouraged, and there should be specific and well-defined roles. Collaborators may or may not reside in Texas. However, collaborators who do not reside in Texas are not eligible to receive CPRIT funds. Subcontracting and collaborating organizations may include public, not-for-profit, and for-profit entities. Such entities may be located outside of the state of Texas, but non-Texas-based organizations are not eligible to receive CPRIT funds.

 

The proposal will be prepared and submitted by Sponsored Research Services (SRS).

 

Proposal Limit: Texas A&M University, 10; Texas A&M University Health Science Center, 10.

 

Summary:  Early Translational Research Awards (ETRAs) are intended to support the development of preclinical studies that establish proof of concept. The current trend in funding by the private sector strongly favors programs with a solid proof of concept that can be undertaken at an acceptable level of risk. Increasingly, for new treatments, this is taken as a clear preclinical indication of a population subset or biomarker approach allowing preselection of the patient population more likely to respond to the therapy.

 

Examples of appropriate projects for the RFA include those that incorporate the study of potential biomarkers of use for the clinic, such as biomarkers for selection of patients (eg, tumors with mutations in EGFR, DDR2, BRAF) and/or biomarkers that can be utilized as pharmacodynamic end points (eg, measurement of bone degradation products in preclinical animal studies and early clinical studies of treatment of bone metastases), tissue distribution, preliminary stability or other “drugability” criteria, or safety pharmacology studies conducted in compliance with International Conference on Harmonization (ICH) Guidelines and, thus, usable in a formal Food and Drug Administration (FDA) regulatory submission. Applicants who plan to perform investigational new drug (IND)-enabling studies should document that they have experience and proficiency in doing such studies. A detailed preclinical development plan that demonstrates the translation of the preclinical work to the eventual clinical studies will be required.

 

Dates:

 

March 15, 2016

Deadline for an email of intent including the title of the internal proposal and a one to three sentence description of the project. 

 

Send email of intent to limitedsubmissions@tamu.edu

March 22, 2016

Deadline to submit an internal proposal.

 

All proposals for the LSP must be submitted electronically using the e-proposal on-line application system.

 

Be prepared to upload your internal proposal. The sections will include a one-three page research plan summary, two-page bio-sketch, and preliminary budget.

 

The e-proposal site is password protected. Texas A&M principal investigators may use their NetID and password to access the system. If you do not have a NetID, click HERE for help to activate your NetID. You will need your UIN and your date of birth.  Once you log-in to e-proposal, choose “Limited Submission Grant” from the Available Grants section.


If you have any questions, please contact:

 shelly.martin@tamu.edu  or 979.862.2233.

 

April 12, 2016

Target date for the notifications to PIs of the result of the internal competition.

May 19, 2016

Sponsor deadline for the full proposal (due by 5:00 p.m. proposer’s local time).

 

 

Internal Selection Procedures:

Texas A&M has established a procedure to identify limited submission opportunities and internally select proposals for Texas A&M submissions.  Please contact us if you have any questions about the limited submission process.

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