Centers for Common Disease Genomics (UM1)

NIH National Human Genome Research Institute

Centers for Common Disease Genomics (UM1)

http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-15-001.html

Limited Submission Program (LSP): This funding opportunity and the Limited Submission Program (LSP) is open to all Texas A&M University faculty and principal investigators who meet the eligibility requirements. Texas A&M and The Texas A&M University System agencies jointly administer this process to select the proposal(s) that will be submitted to the sponsor in response to this solicitation.

Institutional Eligibility:  Only one application per institution is allowed.

PI Eligibility:  Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

The proposal will be prepared and submitted by Sponsored Research Services (SRS).

Proposal Limit: 1

Summary:  The National Human Genome Research Institute (NHGRI) seeks to fund several Centers for Common Disease Genomics (CCDG), which will constitute a collaborative large-scale genome sequencing effort to comprehensively identify rare risk and protective variants contributing to multiple common disease phenotypes. This initiative will explore a range of diseases with the ultimate goal of undertaking variant discovery for enough different examples of disease architectures and study designs to better understand the general principles of genomic architecture underlying common, complex inherited diseases; understand how best to design rare variant studies for common disease; and to develop resources, informatics tools, and innovative approaches and technologies for multiple disease research communities and the wider biomedical research community. This program will pursue these examples as comprehensively as possible---emphasizing whole genome sequencing over whole exome sequencing where feasible--- and also will drive the state-of-the-art in identifying rare variants underlying common disease. In this context, comprehensiveness will be considered broadly, including consideration of, e.g. statistical power, exploring a range of different populations (including those that are currently under-represented in sequencing studies), study designs, and the extent of the genome studied (e.g., whole genomes versus whole exomes). The program will include analysis of the data in order to identify variants associated with risk of, or protection from, disease, and to discern general principles of complex disease architecture. NHGRI expects that this program will need to be highly collaborative between investigators funded by this and other NHGRI programs that span the continuum from inherited disease variant discovery through understanding variant function. NHGRI also anticipates that this program will require a high degree of collaboration with researchers with an interest in particular inherited diseases, both to identify appropriate sample sets (collection of new samples will not be funded under this initiative), to provide domain expertise for study design and analysis, and to ensure that the data and ability to use it are widely disseminated as resources.

Dates:

Internal Selection Procedures:

Texas A&M has established a procedure to identify limited submission opportunities and internally select proposals for Texas A&M submissions.  Please contact us if you have any questions about the limited submission process.