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CPRIT High-Impact/High-Risk Research Awards

Cancer Prevention & Research Institute of Texas (CPRIT)

PI Eligibility:
The Principal Investigator (PI) must have a doctoral degree, including M.D., Ph.D., D.D.S., D.M.D., Dr. P.H., D.O., D.V.M., or equivalent, and must reside in Texas during the time the research that is the subject of the grant is conducted.

Institutional Limit:
Texas A&M University is eligible to submit 5 proposals.
Agrilife, TEES and TTI are eligible to submit 2 proposals each.

Institutional Eligibility:
The applicant must be a Texas-based entity. Any not-for-profit institution that conducts research is eligible to apply for funding under this award mechanism.  For this submission, TAMU, AGRILIFE, TEES meet the institutional eligibility to submit proposals to CPRIT. 

CPRIT High-Impact/High-Risk Research Awards seek to provide short-term funding to explore the feasibility of high-risk projects that, if successful, would contribute major new insights into the etiology, diagnosis, treatment, or prevention of cancers. Because High-Impact/High-Risk Research Awards are designed to support new ideas, preliminary data are not required. Using this mechanism, CPRIT intends to support innovative, developmental projects that focus on exceptionally promising topics that are not yet sufficiently mature to compete successfully for more conventional funding. The High-Impact/High-Risk Research Awards are expected to provide the foundation for individual or multiple investigator awards upon completion. Applicants must explain why more conventional sources of support are not available for the proposed research and how short-term funding will lead to strong applications for additional support. Applications that might be described as “mini-R01s” will not be competitive. The goal of this award mechanism is to fund uncommonly great ideas that merit the opportunity to acquire preliminary data. There should be reasons for the idea to be plausible, but CPRIT acknowledges that most of the selected projects will ultimately fail to meet their primary goals. The rare proposals that succeed will be of sufficient importance to justify this program.

Areas of interest include laboratory research, translational studies, and/or clinical investigations. In that cancers arise from a large number of derangements of basic molecular and cellular functions and in turn cause many alterations in basic biological processes, almost any aspect of biology may be relevant to cancer research, more or less directly. The degree of relevance to cancer research will be an important criterion for evaluation of projects for funding by CPRIT. For example, are alterations in the process in question primarily responsible for oncogenesis or secondary manifestations of malignant transformation? Will understanding the process or interfering with it offer selective and useful insight into prevention, diagnosis, or treatment of cancer?

Applicants may request a total of $200,000 for a period of up to 24 months (2 years), inclusive of both direct and indirect costs. Because of the nature of this funding mechanism, renewal applications will not be accepted. Follow-on applications will not be funded until the time requested for the High-Impact/High-Risk Research Award has passed. Award funds may be used to pay for salary and benefits, research supplies, equipment, and clinical costs. Requests for funds for travel to scientific meetings are not appropriate for this funding mechanism, nor are requests for funds to support construction and/or renovation. State law limits the amount of award funding that may be spent on indirect costs to no more than 5 percent of the total award amount.

March 6, 2012:
  Deadline for an email of intent, including the names of the PI, title of internal proposal and a 1-3 sentence description of the project.

Send email of intent to

March 23, 2012, 5:00 pm: Deadline to submit an internal proposal.  
All proposals submitted for the Limited Submissions Awards must be submitted electronically using the on-line application system, which is available at:

Instructions for internal proposal:  Be prepared to upload a preliminary… executive summary, cv’s. budget.

This site is password protected. Texas A&M University tenure or tenure track faculty may use their neo password to access the system. To change your password go to:, click on "Forget your password?" and enter the email account you used to setup your account.  If you need to setup a new account go to:, click on "Need an eProposal Account," fill in the pertinent information and an account will be created for you.

If you have any questions, please contact or 979.845.1811.

April 5, 2012: The Internal Selection Committee will notify PIs of the result of the internal competition.

May 31, 20120, 3:00 pm:  Deadline for the full proposal.

Internal Selection Procedures:
Texas A&M University has established a process to identify limited submission opportunities and internally select applications for Texas A&M submissions.