High Impact/High-Risk Research Awards

Cancer Research and Prevention Institute of Texas (CPRIT)

http://www.cprit.state.tx.us/funding-opportunities/

Limited Submission Program (LSP): This funding opportunity and the Limited Submission Program (LSP) is open to all Texas A&M University faculty and principal investigators who meet the eligibility requirements. Texas A&M and The Texas A&M University System agencies jointly administer this process to select the proposal(s) that will be submitted to the sponsor in response to this solicitation.

Institutional Eligibility: The applicant must be a Texas-based entity. Any not-for-profit institution or organization that conducts research is eligible to apply for funding under this award mechanism. A public or private company is also eligible for funding under this award mechanism.

PI Eligibility:
•    The Principal Investigator (PI) must have a doctoral degree, including M.D., Ph.D., D.D.S., D.M.D., Dr.P.H., D.O., D.V.M., or equivalent, and reside in Texas for the period of the time that the research that is the subject of the grant is conducted.
•    A PI may submit only one new or resubmission application under this RFA during this funding cycle.
•    One Co-PI may be included.
•    Collaborations are permitted and encouraged, and collaborators may or may not reside in Texas. However, collaborators who do not reside in Texas are not eligible to receive CPRIT funds. Collaborators should have specific and well-defined roles. Subcontracting and collaborating organizations may include public, not-for-profit, and for-profit entities. Such entities may be located outside of the State of Texas, but non-Texas–based organizations are not eligible to receive CPRIT funds.
•    An applicant is eligible to receive a grant award only if the applicant certifies that the applicant institution or organization, including the PI, any senior member or key personnel listed on the grant application, and any officer or director of the grant applicant’s institution or organization (or any person related to one or more of these individuals within the second degree of consanguinity or affinity), have not made and will not make a contribution to CPRIT or to any foundation specifically created to benefit CPRIT.
•    An applicant is not eligible to receive a CPRIT grant award if the applicant PI, any senior member or key personnel listed on the grant application, and any officer or director of the grant applicant’s institution or organization is related to a CPRIT Oversight Committee member.
•    The applicant must report whether the applicant institution or organization, the PI, or other individuals who contribute to the execution of the proposed project in a substantive, measurable way, whether or not those individuals are slated to receive salary or compensation under the grant award, are currently ineligible to receive Federal grant funds or have had a grant terminated for cause within 5 years prior to the submission date of the grant application.
•    CPRIT grants will be awarded by contract to successful applicants. Certain contractual requirements are mandated by Texas law or by administrative rules. Although applicants need not demonstrate the ability to comply with these contractual requirements at the time the application is submitted, applicants should make themselves aware of these standards before submitting a grant application. Significant issues addressed by the CPRIT contract are listed in Section 10 and Section 11. All statutory provisions and relevant administrative rules can be found at www.cprit.state.tx.us.

The proposal will be prepared and submitted by Sponsored Research Services (SRS).

Proposal Limits:

Texas A&M University – 5
Health Science Center – 5
AgriLife Research – 2
TEES - 2


Summary: CPRIT High-Impact/High-Risk (HIHR) Research Awards seek to provide short-term funding to explore the feasibility of high-risk projects that, if successful, would contribute major new insights into the etiology, diagnosis, treatment, or prevention of cancers. Because HIHR Research Awards are designed to support new ideas, preliminary data are not required. Using this mechanism, CPRIT intends to support innovative, developmental projects that focus on exceptionally promising topics that are not yet sufficiently mature to compete successfully for more conventional funding. The HIHR Research Awards are expected to provide the foundation for individual or multiple investigator awards upon completion. Applicants must explain why more conventional sources of support are not available for the proposed research and how short-term funding will lead to strong applications for additional support.

Applications that might be described as“mini-R01s”will not be competitive. The goal of this award mechanism is to fund uncommonly great ideas that merit the opportunity to acquire preliminary data. There should be reasons for the idea to be plausible, but CPRIT acknowledges that most of the selected projects will ultimately fail to meet their primary goals. The rare proposals that succeed will be of sufficient importance to justify this program. Applications may address any research topic related to cancer biology, causation, prevention, detection, screening, or treatment.

Areas of interest include laboratory research, translational studies, population-based and/or clinical investigations. In that cancers arise from a large number of derangements of basic molecular and cellular functions, which, in turn, cause many alterations in basic biological processes, almost any aspect of biology may be relevant to cancer research, more or less directly. The degree of relevance to cancer research will be an important criterion for evaluation of projects for funding by CPRIT (Section 8.3.1). For example, are alterations in the process in question primarily responsible for oncogenesis or secondary manifestations of malignant transformation? Will understanding the process or interfering with it offer selective and useful insight into prevention, diagnosis, or treatment of cancer? Successful applicants for funding from CPRIT will have addressed these questions satisfactorily.

Applicants may request a total of $200,000 for a period of up to 24 months (2 years), inclusive of both direct and indirect costs. Because of the nature of this funding mechanism, renewal applications will not be accepted. Follow-on applications will not be funded until the time requested for the HIHR Research Award has passed. Award funds may be used to pay for salary and benefits, research supplies, equipment, and clinical costs. Requests for funds for travel to scientific meetings are not appropriate for this funding mechanism, nor are requests for funds to support construction and/or renovation. State law limits the amount of award funding that may be spent on indirect costs to no more than 5 percent of the total award amount.

Dates:

August 29, 2014: Deadline for an email of intent including the title of the internal proposal and a one to three sentence description of the project.

Send email of intent to limitedsubmissions@tamu.edu

September 3, 2014: Deadline to submit an internal proposal.

All proposals for the LSP must be submitted electronically using the e-proposal on-line application system.

Be prepared to upload your internal proposal. The sections will include a one-three page research plan summary, two-page bio-sketch, and preliminary budget.

The e-proposal site is password protected. Texas A&M principal investigators may use their NetID and password to access the system. If you do not have a NetID, click HERE for help to activate your NetID. You will need your UIN and your date of birth.

If you have any questions, please contact:  shelly.martin@tamu.edu or 979.862.2233.

September 24, 2014: Target date for the notifications to PIs of the result of the internal competition.

November 17, 2014: Sponsor deadline for the full application (due by 3:00 p.m. Central Time).  

Internal Selection Procedures:
Texas A&M has established a procedure to identify limited submission opportunities and internally select proposals for Texas A&M submissions. Please contact us if you have any questions about the limited submission process.

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